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Program
Sunday, July 10, 2022
| Time | Event | (+) |
| 16:00 - 17:40 | Registration & Welcome Drinks - Registration at the front desk of the Palais de la Bourse (19, Place de la Bourse, 33000 Bordeaux) | |
| 17:40 - 17:55 | Opening remarks (Main hall (Espace de la Bourse)) | |
| 17:55 - 18:40 | Keynote Lecture I (Main hall (Espace de la Bourse)) - Jody Puglisi | |
| 18:40 - 20:00 | Ribosome biogenesis and proto-ribosomes (Main hall (Espace de la Bourse)) | (+) |
| 18:40 - 19:00 | › A cold look at the formation and activation of the bacterial large ribosomal subunit - Christian Spahn | |
| 19:00 - 19:20 | › Early Intermediates in 50S ribosome assembly - James Williamson | |
| 19:20 - 19:40 | › Translationally active proto-ribosomes with smaller rRNA - Jessica Willi | |
| 19:40 - 20:00 | › The proto-ribosome as the kernel of origin of life - Ada Yonath |
Monday, July 11, 2022
| Time | Event | (+) |
| 09:00 - 10:40 | Initiation (Main hall (Espace de la Bourse)) | (+) |
| 09:00 - 09:20 | › Dissecting ribosome and translation initiation factor binding using high throughput approaches reveals novel regulatory elements in 5′-UTRs - Ritam Neupane | |
| 09:20 - 09:40 | › GTP hydrolysis by eIF2 and binding of eIF5B rearrange the human 48S initiation complex for 60S subunit joining - Niels Fischer | |
| 09:40 - 10:00 | › Structure of a human 48S reveals how eIF4F and eIF4A regulate translation initiation - Jailson Brito Querido | |
| 10:00 - 10:20 | › The structural dynamics of mRNA recruitment during eukaryotic translation initiation - Riley Gentry | |
| 10:20 - 10:40 | › Compact IF2 gates the ribosome to elongation - Matthieu Gagnon | |
| 10:40 - 11:20 | Coffee break (Main hall (Espace de la Bourse)) | |
| 11:20 - 12:40 | Decoding and elongation I (Main hall (Espace de la Bourse)) | (+) |
| 11:20 - 11:40 | › Geometric alignment of aminoacyl-tRNA relative to catalytic centers of the ribosome underpins accurate mRNA decoding - Karissa Sanbonmatsu | |
| 11:40 - 12:00 | › Structural insights into the decoding capability of tRNA with cytidine modifications - Naho Akiyama | |
| 12:00 - 12:20 | › Codon position-specific engineering of translation kinetics monitored by Live Imaging on Single Cell Arrays (LISCA) - Sophia Rudorf | |
| 12:20 - 12:40 | › Impact of ribosomes, mRNA sequence and nascent protein chain on efficiency and accuracy of protein synthesis - Sergej Djuranovic | |
| 12:40 - 14:00 | Lunch (Main hall (Espace de la Bourse)) | |
| 14:00 - 16:00 | Decoding and elongation II (Main hall (Espace de la Bourse)) | (+) |
| 14:00 - 14:20 | › Specific length and structure rather than high thermodynamic stability enable regulatory mRNA stem-loops to pause translation - Dmitri Ermolenko | |
| 14:20 - 14:40 | › Insights into the ribosome function from the structures of non-arrested ribosome nascent chain complexes. - Yury Polikanov | |
| 14:40 - 15:00 | › Variable sequences in the Archaeal A loop stabilize the bacterial ribosome - Amos Nissley | |
| 15:00 - 15:20 | › Revealing transient processes governing translation through the integration of single-molecule imaging and cryo-electron microscopy - Scott Blanchard | |
| 15:20 - 15:40 | › Ribosome stalling in Huntington disease - Srinivasa Subramaniam | |
| 15:40 - 16:00 | › Alexander Spirin (1931-2020). Role of diphthamide in the ribosomal translocation. E-site specificity of Candida albicans ribosome. - Marat Yusupov | |
| 16:00 - 16:40 | Coffee break (Main hall (Espace de la Bourse)) | |
| 16:40 - 18:20 | Disrupted elongation and termination (Main hall (Espace de la Bourse)) | (+) |
| 16:40 - 17:00 | › Nascent peptide-induced translation discontinuation in eukaryotes impacts biased amino acid usage in proteomes. - Yuhei Chadani | |
| 17:00 - 17:20 | › How the ribosome shifts to the +1-frame - Ya-Ming Hou | |
| 17:20 - 17:40 | › Start codon-associated ribosomal frameshifting mediates nutrient stress adaptation - Shu-Bing Qian | |
| 17:40 - 18:00 | › Single-molecule imaging in cells reveals the dynamics of programmed stop-codon readthrough by ribosomes - Nicholas Guydosh | |
| 18:00 - 18:20 | › New results on dynamic processes in eubacterial and eukaryotic translation from time-resolved cryo-EM - Joachim Frank | |
| 18:20 - 20:30 | Drinks & finger food | Poster Session I (Main hall (Espace de la Bourse)) |
Tuesday, July 12, 2022
| Time | Event | (+) |
| 09:00 - 10:40 | Co-translational folding and targeting (Main hall (Espace de la Bourse)) | (+) |
| 09:00 - 09:20 | › The role of NAC in SRP mediated protein targeting to the ER - Nenad Ban | |
| 09:20 - 09:40 | › AP Profiling: Resolving co-translational protein folding pathways in vivo - Christian Kaiser | |
| 09:40 - 10:00 | › Cotranslational folding of cytosolic and membrane proteins - Marina Rodnina | |
| 10:00 - 10:20 | › Structural biology of protein folding on the ribosome - John Christodoulou | |
| 10:20 - 10:40 | › Structural studies of protein folding and misfolding during biogenesis on the ribosome - Lisa Cabrita | |
| 10:40 - 11:20 | Coffee break (Main hall (Espace de la Bourse)) | |
| 11:20 - 12:20 | Stress response (Main hall (Espace de la Bourse)) | (+) |
| 11:20 - 11:40 | › (p)ppGpp controls stringent factors by exploiting antagonistic allosteric coupling between catalytic domains - Vasili Hauryliuk | |
| 11:40 - 12:00 | › RelA-SpoT Homolog toxins pyrophosphorylate the CCA end of tRNA to inhibit protein synthesis - Tatsuaki Kurata | |
| 12:00 - 12:20 | › Structural insights into ribosomal triggering of stress responses. - Andrei Korostelev | |
| 12:20 - 13:00 | Methods (Main hall (Espace de la Bourse)) | (+) |
| 12:20 - 12:40 | › Effects of cryo-EM cooling on structural ensembles - Helmut Grubmueller | |
| 12:40 - 13:00 | › Single-molecule tracking for kinetics measurements of protein synthesis, folding, and targeting inside living cells - Mikhail Metelev | |
| 13:00 - 14:00 | Box lunch | |
| 14:00 - 18:00 | Free time - Optional tours of Bordeaux Center, Arcachon or Saint-Emilion (separate registration required) |
Wednesday, July 13, 2022
| Time | Event | (+) |
| 09:00 - 10:40 | Quality control in translation I (Main hall (Espace de la Bourse)) | (+) |
| 09:00 - 09:20 | › An E3 ligase network engages GCN1 to promote elongation factor-1a degradation on stalled ribosomes - Jack Taunton | |
| 09:20 - 09:40 | › Mechanism of ribosome-associated mRNA degradation in the tubulin autoregulation pathway - Markus Höpfler | |
| 09:40 - 10:00 | › Mechanistic insights into ribosomal protein degradation - Sichen Shao | |
| 10:00 - 10:20 | › Ribosome collisions induce mRNA cleavage and ribosome rescue in bacteria - Allen Buskirk | |
| 10:20 - 10:40 | › Ribosome collisions, quality control and stress response - Hani Zaher | |
| 10:40 - 11:20 | Coffee break (Main hall (Espace de la Bourse)) | |
| 11:20 - 12:40 | Quality control in translation II (Main hall (Espace de la Bourse)) | (+) |
| 11:20 - 11:40 | › ROS-induced ribosome pausing underlies ZAK-alpha-mediated metabolic decline in obesity and aging - Simon Bekker-Jensen | |
| 11:40 - 12:00 | › GCN2 activation by ribosome stalling – a sensor of disease-associated alterations in translation dynamics - Zoya Ignatova | |
| 12:00 - 12:20 | › Sensing and Targeting of Individual Stalled 80S Ribosomes for Non-functional rRNA Turnover - Sihan Li | |
| 12:20 - 12:40 | › Structural studies of co-translational quality control - Petr Tesina | |
| 12:40 - 14:00 | Lunch (Main hall (Espace de la Bourse)) | |
| 14:00 - 16:00 | Antibiotics and resistance (Main hall (Espace de la Bourse)) | (+) |
| 14:00 - 14:20 | › Ribosomal antibiotics as modulators of translation - Alexander Mankin | |
| 14:20 - 14:40 | › Context-dependent inhibition of bacterial protein synthesis by ribosome-targeting antibiotics - Axel Innis | |
| 14:40 - 15:00 | › Context-Specific Inhibition of Translation by Oxazolidinone Antibiotics - Danica Galonic Fujimori | |
| 15:00 - 15:20 | › Ribosome-targeting antibiotics and bacterial resistance mechanisms - Daniel Wilson | |
| 15:20 - 15:40 | › Cryo-EM studies of all four E. coli ABCF paralogs establish the general principles underlying reciprocal allosteric linkage of the ATPase activity of ABCF proteins to global ribosome conformation and PTC structure - Shikha Singh | |
| 15:40 - 16:00 | › Complementary mechanisms of ribosome inhibition by known antibiotics - Pohl Milon | |
| 16:00 - 16:40 | Coffee break (Main hall (Espace de la Bourse)) | |
| 16:40 - 18:20 | Alternative ribosome forms (Main hall (Espace de la Bourse)) | (+) |
| 16:40 - 17:00 | › A human rRNA catalog, the Ribome, associates with development, aging, and cancer - Daphna Rothschild | |
| 17:00 - 17:20 | › Expanding our knowledge on rRNA functions: expansion segments as modulators of the eukaryal ribosome - Robert Rauscher | |
| 17:20 - 17:40 | › Evolution of biological novelty through ribosome specialization - Amy Lee | |
| 17:40 - 18:00 | › Ribosomes lacking bS21 gain function to regulate protein synthesis - Kurt Fredrick | |
| 18:00 - 18:20 | › Ribosme interactome recomposition by viruses - Thibault Sohier | |
| 18:20 - 20:30 | Drinks & finger food | Poster Session II (Main hall (Espace de la Bourse)) |
Thursday, July 14, 2022
| Time | Event | (+) |
| 09:00 - 09:45 | Keynote Lecture II (Main hall (Espace de la Bourse)) - Rachel Green | |
| 09:45 - 11:05 | Ribosomes in organelles and pathogens (Main hall (Espace de la Bourse)) | (+) |
| 09:45 - 10:05 | › Activation mechanism of mitochondrial translation by LRPPRC-SLIRP - Alexey Amunts | |
| 10:05 - 10:25 | › Human mitochondria require mtRF1 for translation termination at non-canonical stop codons - Joanna Rorbach | |
| 10:25 - 10:45 | › The Giardia lamblia ribosome structure at 2.49 Å reveals divergence in several biological pathways and the mode of emetine function - Jeffrey Kieft | |
| 10:45 - 11:05 | › Translocation Intermediates of Giardia intestinalis Ribosome Provide Insights into the Evolution of Eukaryotic Translation Machinery - Suparna Sanyal | |
| 11:05 - 11:35 | Coffee break (Main hall (Espace de la Bourse)) | |
| 11:35 - 13:15 | Regulation of translation (Main hall (Espace de la Bourse)) | (+) |
| 11:35 - 11:55 | › eIF5A is a Sensor and Effector for Polyamine Regulation of Translation - Ivaylo Ivanov - National Institutes of Health | |
| 11:55 - 12:15 | › ANTIBIOTIC RESISTANCE OR SIGNALING? The role of ABCF-ATPases in antibiotic producers. - Gabriela Balíková Novotná - Institute of Microbiology of the Czech Academy of Sciences, BIOCEV, Vestec, Czech Republic | |
| 12:15 - 12:35 | › The ABC-F protein EttA regulates specific protein synthesis by alleviating early ribosomal translational stalling during mRNA translation. - Gregory Boel - CNRS/Université de Paris Cité UMR 8261 - IBPC 13, rue Pierre et Marie Curie 75005 Paris | |
| 12:35 - 12:55 | › A new paradigm in virus-host arms race: How does the host encoded ZAP-S alter conformational dynamics and translation of frameshifting RNAs? - Neva Caliskan | |
| 12:55 - 13:15 | › Alterations in mRNA translation initiation in colorectal cancer - Yaser Hashem | |
| 13:15 - 19:00 | Free time | |
| 19:00 - 22:30 | Closing Gala (Main hall (Espace de la Bourse)) |
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